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- Title
Clinicopathologic Characterization of Post-Renal Transplantation BK Polyomavirus-Associated Urothelial CarcinomaSingle Institutional Experience.
- Authors
Chu, Ying-Hsia; Zhong, Weixiong; Rehrauer, William; Pavelec, Derek M; Ong, Irene M; Arjang, Djamali; Patel, Sanjay S; Hu, Rong
- Abstract
<bold>Objectives: </bold>To review rare cases of BK polyomavirus (BKPyV) associated urologic carcinomas in kidney transplant recipients at one institution and in the literature.<bold>Methods: </bold>We describe the clinicopathologic features of BKPyV-associated urologic carcinomas in a single-institution cohort.<bold>Results: </bold>Among 4,772 kidney recipients during 1994 to 2014, 26 (0.5%) and 26 (0.5%) developed posttransplantation urothelial carcinomas (UCs) and renal cell carcinomas (RCCs), respectively, as of 2017. Six (27%) UCs but none of the RCCs expressed large T antigen (TAg). TAg-expressing UCs were high grade with p16 and p53 overexpression (P < .05 compared to TAg-negative UCs). Tumor genome sequencing revealed BKPyV integration and a lack of pathogenic mutations in 50 cancer-relevant genes. Compared to TAg-negative UCs, TAg-expressing UCs more frequently presented at advanced stages (50% T3-T4) with lymph node involvement (50%) and higher UC-specific mortality (50%).<bold>Conclusions: </bold>Post-renal transplantation BKPyV-associated UCs are aggressive and genetically distinct from most non-BKPyV-related UCs.
- Subjects
RENAL cell carcinoma; TRANSITIONAL cell carcinoma; TRANSPLANTATION of organs, tissues, etc.; KIDNEY transplantation; TUMOR antigens; P16 gene; COMPARATIVE studies; KIDNEYS; KIDNEY tumors; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SURGICAL complications; TUMORS; VIRUSES; EVALUATION research; POLYOMAVIRUS diseases; RETROSPECTIVE studies
- Publication
American Journal of Clinical Pathology, 2020, Vol 153, Issue 3, p303
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqz167