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Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy.
- Published in:
- Journal of Hematology & Oncology, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13045-020-00929-8
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- Publication type:
- Article
Bcl-2 changes conformation to inhibit Bax oligomerization.
- Published in:
- EMBO Journal, 2006, v. 25, n. 11, p. 2287, doi. 10.1038/sj.emboj.7601126
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- Publication type:
- Article
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.
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- EMBO Journal, 2005, v. 24, n. 12, p. 2096, doi. 10.1038/sj.emboj.7600675
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- Publication type:
- Article
Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis.
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- EMBO Journal, 2001, v. 20, n. 21, p. 5999, doi. 10.1093/emboj/20.21.5999
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- Publication type:
- Article
Small molecules reveal an alternative mechanism of Bax activation.
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- Biochemical Journal, 2016, v. 473, n. 8, p. 1073, doi. 10.1042/BCJ20160118
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- Publication type:
- Article
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.
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- Biochemical Journal, 2015, v. 467, n. 3, p. 495, doi. 10.1042/BJ20141291
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- Publication type:
- Article
The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells.
- Published in:
- eLife, 2020, p. 1, doi. 10.7554/eLife.44525
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- Publication type:
- Article
Consensus Recommendations for MRD Testing in Adult B-Cell Acute Lymphoblastic Leukemia in Ontario.
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- Current Oncology, 2021, v. 28, n. 2, p. 1376, doi. 10.3390/curroncol28020131
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- Publication type:
- Article
Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.
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- Stem Cells, 2015, v. 33, n. 6, p. 1839, doi. 10.1002/stem.1994
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- Publication type:
- Article
Final report of TKI discontinuation trial with dasatinib for the second attempt of treatment‐free remission after failing the first attempt with imatinib: Treatment‐free Remission Accomplished by Dasatinib (TRAD) study.
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- British Journal of Haematology, 2023, v. 203, n. 5, p. 781, doi. 10.1111/bjh.19058
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- Publication type:
- Article
BCR–ABL1 transcript doubling time as a predictor for treatment‐free remission failure after imatinib discontinuation in chronic myeloid leukaemia in chronic phase.
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- British Journal of Haematology, 2022, v. 196, n. 1, p. 136, doi. 10.1111/bjh.17807
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- Publication type:
- Article
Patient‐reported fatigue refines prognosis in higher‐risk myelodysplastic syndromes (MDS): a MDS‐CAN study.
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- British Journal of Haematology, 2021, v. 194, n. 2, p. 319, doi. 10.1111/bjh.17537
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- Publication type:
- Article
Optimal duration of imatinib treatment/deep molecular response for treatment‐free remission after imatinib discontinuation from a Canadian tyrosine kinase inhibitor discontinuation trial.
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- British Journal of Haematology, 2021, v. 193, n. 4, p. 779, doi. 10.1111/bjh.17447
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- Publication type:
- Article
Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient-related factors and measuring from time of first red blood cell transfusion dependence: an MDS- CAN analysis.
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- British Journal of Haematology, 2017, v. 179, n. 1, p. 83, doi. 10.1111/bjh.14825
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- Publication type:
- Article
Patient-related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS- CAN prospective study.
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- British Journal of Haematology, 2016, v. 174, n. 1, p. 88, doi. 10.1111/bjh.14033
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- Publication type:
- Article
Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O<sup>6</sup>-methylguanine DNA methyltransferase expression.
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- British Journal of Haematology, 2014, v. 167, n. 5, p. 664, doi. 10.1111/bjh.13094
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- Publication type:
- Article
Optimizing the Acquisition and Analysis of Confocal Images for Quantitative Single-Mobile-Particle Detection.
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- ChemPhysChem, 2013, v. 14, n. 11, p. 2476, doi. 10.1002/cphc.201201047
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- Publication type:
- Article
Circumvention of Fluorophore Photobleaching in Fluorescence Fluctuation Experiments: a Beam Scanning Approach.
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- ChemPhysChem, 2007, v. 8, n. 6, p. 834, doi. 10.1002/cphc.200600589
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- Publication type:
- Article
Long‐term follow‐up of VIALE‐A: Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia.
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- American Journal of Hematology, 2024, v. 99, n. 4, p. 615, doi. 10.1002/ajh.27246
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- Publication type:
- Article
Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Combined results from two randomized controlled feasibility studies.
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- American Journal of Hematology, 2024, v. 99, n. 3, p. 473, doi. 10.1002/ajh.27181
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- Publication type:
- Article
Perioperative management of myeloproliferative neoplasms: A pan‐Canadian physician survey and international expert opinion.
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- American Journal of Hematology, 2022, v. 97, n. 12, p. E466, doi. 10.1002/ajh.26739
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- Publication type:
- Article
The impact of oral hypoglycemics and statins on outcomes in myelodysplastic syndromes.
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- Annals of Hematology, 2022, v. 101, n. 5, p. 1023, doi. 10.1007/s00277-022-04802-1
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- Publication type:
- Article
Correction to: Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial.
- Published in:
- 2021
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- Publication type:
- corrected article
Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial.
- Published in:
- 2021
- By:
- Publication type:
- journal article
A predictive model of response to erythropoietin stimulating agents in myelodysplastic syndrome: from the Canadian MDS patient registry.
- Published in:
- 2017
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- Publication type:
- journal article
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.
- Published in:
- EMBO Reports, 2018, v. 19, n. 9, p. 1, doi. 10.15252/embr.201745235
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- Publication type:
- Article
Laboratory Investigation of Myeloproliferative Neoplasms (MPNs): Recommendations of the Canadian Mpn Group.
- Published in:
- 2016
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- Publication type:
- journal article
Laboratory Investigation of Myeloproliferative Neoplasms (MPNs).
- Published in:
- American Journal of Clinical Pathology, 2016, v. 146, n. 4, p. 408, doi. 10.1093/AJCP/AQW131
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- Publication type:
- Article
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event.
- Published in:
- Oncogene, 2001, v. 20, n. 16, p. 1939, doi. 10.1038/sj.onc.1204288
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- Publication type:
- Article
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator.
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- Oncogene, 2000, v. 19, n. 3, p. 329, doi. 10.1038/sj.onc.1203298
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- Publication type:
- Article
Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts.
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- Oncogene, 1999, v. 18, n. 23, p. 3520, doi. 10.1038/sj.onc.1202716
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- Publication type:
- Article
At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes.
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- Oncogene, 1998, v. 17, n. 5, p. 565, doi. 10.1038/sj.onc.1201979
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- Publication type:
- Article
How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry.
- Published in:
- European Journal of Haematology, 2019, v. 102, n. 1, p. 36, doi. 10.1111/ejh.13176
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- Publication type:
- Article
Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.
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- European Journal of Haematology, 2016, v. 96, n. 4, p. 360, doi. 10.1111/ejh.12597
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- Publication type:
- Article
Cyclic thrombocytopenia with statistically significant neutrophil oscillations.
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- Clinical Case Reports, 2018, v. 6, n. 7, p. 1347, doi. 10.1002/ccr3.1611
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- Publication type:
- Article
Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature.
- Published in:
- 2015
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- Publication type:
- Case Study
Clinical Benefit of Glasdegib Plus Low-Dose Cytarabine in Patients with De Novo and Secondary Acute Myeloid Leukemia: Long-Term Analysis of a Phase 2 Randomized Trial.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2019, v. 19, p. S231, doi. 10.1016/j.clml.2019.07.116
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- Publication type:
- Article
Evolving Therapeutic Options for Polycythemia Vera: Perspectives of the Canadian Myeloproliferative Neoplasms Group.
- Published in:
- 2015
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- Publication type:
- journal article
The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.88329
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- Publication type:
- Article
Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: Results of a pilot randomized trial RBC‐ENHANCE.
- Published in:
- Transfusion, 2024, v. 64, n. 2, p. 223, doi. 10.1111/trf.17721
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- Publication type:
- Article
Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax.
- Published in:
- PLoS Biology, 2008, v. 6, n. 6, p. e147, doi. 10.1371/journal.pbio.0060147
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- Publication type:
- Article
Radiotherapy to control CNS lymphomatoid granulomatosis: A case report and review of the literature.
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- American Journal of Hematology, 1999, v. 62, n. 4, p. 239, doi. 10.1002/(SICI)1096-8652(199912)62:4<239::AID-AJH7>3.0.CO;2-U
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- Publication type:
- Article
Morphology of acute promyelocytic leukemia with cytogenetic or molecular evidence for the diagnosis: Characterization of additional microgranular variants.
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- American Journal of Hematology, 1997, v. 56, n. 3, p. 131, doi. 10.1002/(SICI)1096-8652(199711)56:3<131::AID-AJH1>3.0.CO;2-Z
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- Publication type:
- Article
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
- Published in:
- Nature, 2014, v. 511, n. 7507, p. 90, doi. 10.1038/nature13283
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- Publication type:
- Article
Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma.
- Published in:
- British Journal of Haematology, 2008, v. 143, n. 3, p. 355, doi. 10.1111/j.1365-2141.2008.07353.x
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- Publication type:
- Article
Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes.
- Published in:
- Apoptosis, 2007, v. 12, n. 5, p. 897, doi. 10.1007/s10495-007-0746-4
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- Publication type:
- Article
Real-World Treatment Patterns and Clinical Outcomes in Canadian Patients with AML Unfit for First-Line Intensive Chemotherapy.
- Published in:
- Current Oncology, 2022, v. 29, n. 10, p. 6794, doi. 10.3390/curroncol29100535
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- Publication type:
- Article
B-cell lymphoma of recipient origin 9 years after allogeneic bone marrow transplantation for T-cell acute lymphoblastic leukaemia.
- Published in:
- British Journal of Haematology, 1993, v. 85, n. 1, p. 99, doi. 10.1111/j.1365-2141.1993.tb08651.x
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- Publication type:
- Article
Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line.
- Published in:
- BMC Cancer, 2006, v. 6, p. 213, doi. 10.1186/1471-2407-6-213
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- Publication type:
- Article