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- Title
C-C chemokine receptor 1 expression in human hematolymphoid neoplasia.
- Authors
Anderson, Matthew W; Zhao, Shuchun; Ai, Weiyun Z; Tibshirani, Robert; Levy, Ronald; Lossos, Izidore S; Natkunam, Yasodha
- Abstract
Chemokine receptor 1 (CCR1) is a G protein-coupled receptor that binds to members of the C-C chemokine family. Recently, CCL3 (MIP-1alpha), a high-affinity CCR1 ligand, was identified as part of a model that independently predicts survival in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of chemokine signaling in the pathogenesis of human lymphomas is unclear. In normal human hematopoietic tissues, we found CCR1 expression in intraepithelial B cells of human tonsil and granulocytic/monocytic cells in the bone marrow. Immunohistochemical analysis of 944 cases of hematolymphoid neoplasia identified CCR1 expression in a subset of B- and T-cell lymphomas, plasma cell myeloma, acute myeloid leukemia, and classical Hodgkin lymphoma. CCR1 expression correlated with the non-germinal center subtype of DLBCL but did not predict overall survival in follicular lymphoma. These data suggest that CCR1 may be useful for lymphoma classification and support a role for chemokine signaling in the pathogenesis of hematolymphoid neoplasia.
- Subjects
PROTEIN metabolism; B cells; BONE marrow; CELL receptors; CHI-squared test; CLUSTER analysis (Statistics); GRANULOCYTES; DIGITAL image processing; IMMUNOHISTOCHEMISTRY; LYMPHOMAS; MULTIPLE myeloma; TONSILS; ACUTE myeloid leukemia; KAPLAN-Meier estimator
- Publication
American Journal of Clinical Pathology, 2010, Vol 133, Issue 3, p473
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1309/AJCP1TA3FLOQTMHF