Found: 27
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Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling.
- Published in:
- Biotechnology Progress, 2023, v. 39, n. 5, p. 1, doi. 10.1002/btpr.3354
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- Publication type:
- Article
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth.
- Published in:
- Biotechnology Progress, 2023, v. 39, n. 3, p. 1, doi. 10.1002/btpr.3337
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- Article
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study.
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- Biotechnology Progress, 2022, v. 38, n. 6, p. 1, doi. 10.1002/btpr.3290
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- Publication type:
- Article
Bax and Bak knockout apoptosis‐resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed‐batch culture process.
- Published in:
- Biotechnology Progress, 2022, v. 38, n. 2, p. 1, doi. 10.1002/btpr.3228
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- Publication type:
- Article
Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle.
- Published in:
- Biotechnology Progress, 2021, v. 37, n. 5, p. 1, doi. 10.1002/btpr.3193
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- Publication type:
- Article
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange system.
- Published in:
- Biotechnology Progress, 2021, v. 37, n. 4, p. 1, doi. 10.1002/btpr.3140
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- Publication type:
- Article
Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position.
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- Biotechnology Progress, 2020, v. 36, n. 4, p. 1, doi. 10.1002/btpr.2967
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- Article
Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum‐free media.
- Published in:
- Biotechnology Progress, 2020, v. 36, n. 3, p. 1, doi. 10.1002/btpr.2951
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- Publication type:
- Article
Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express.
- Published in:
- Biotechnology Progress, 2019, v. 35, n. 2, p. N.PAG, doi. 10.1002/btpr.2772
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- Article
Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality.
- Published in:
- Biotechnology Progress, 2018, v. 34, n. 3, p. 624, doi. 10.1002/btpr.2594
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- Publication type:
- Article
Development and characterization of an automated imaging workflow to generate clonally‐derived cell lines for therapeutic proteins.
- Published in:
- Biotechnology Progress, 2018, v. 34, n. 3, p. 584, doi. 10.1002/btpr.2561
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- Article
Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally‐derived or not.
- Published in:
- Biotechnology Progress, 2018, v. 34, n. 3, p. 559, doi. 10.1002/btpr.2560
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- Publication type:
- Article
Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.
- Published in:
- Biotechnology Progress, 2017, v. 33, n. 3, p. 786, doi. 10.1002/btpr.2444
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- Publication type:
- Article
Taming hyperactive h DNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells.
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- Biotechnology Progress, 2017, v. 33, n. 2, p. 523, doi. 10.1002/btpr.2439
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- Publication type:
- Article
Slashing the timelines: Opting to generate high-titer clonal lines faster via viability-based single cell sorting.
- Published in:
- Biotechnology Progress, 2016, v. 32, n. 1, p. 198, doi. 10.1002/btpr.2204
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- Publication type:
- Article
It's time to regulate: Coping with product-induced nongenetic clonal instability in CHO cell lines via regulated protein expression.
- Published in:
- Biotechnology Progress, 2014, v. 30, n. 6, p. 1432, doi. 10.1002/btpr.1970
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- Publication type:
- Article
Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies.
- Published in:
- Biotechnology Progress, 2013, v. 29, n. 5, p. 1307, doi. 10.1002/btpr.1783
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- Publication type:
- Article
Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production.
- Published in:
- Biotechnology Progress, 2013, v. 29, n. 3, p. 727, doi. 10.1002/btpr.1722
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- Publication type:
- Article
High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain.
- Published in:
- Biotechnology & Bioengineering, 2004, v. 85, n. 5, p. 463, doi. 10.1002/bit.20014
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- Article
Metabolic oscillations in an E. coli fermentation.
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- Biotechnology & Bioengineering, 2001, v. 75, n. 2, p. 212, doi. 10.1002/bit.10018
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- Article
FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
- Published in:
- Biotechnology & Bioengineering, 2017, v. 114, n. 3, p. 632, doi. 10.1002/bit.26188
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- Publication type:
- Article
Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells.
- Published in:
- Biotechnology & Bioengineering, 2010, v. 107, n. 1, p. 163, doi. 10.1002/bit.22780
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- Publication type:
- Article
Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules.
- Published in:
- Biotechnology Journal, 2021, v. 16, n. 4, p. 1, doi. 10.1002/biot.202000230
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- Publication type:
- Article
Pyruvate Kinase Muscle‐1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
- Published in:
- Biotechnology Journal, 2019, v. 14, n. 4, p. N.PAG, doi. 10.1002/biot.201800332
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- Publication type:
- Article
High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.
- Published in:
- Biotechnology Journal, 2018, v. 13, n. 10, p. 1, doi. 10.1002/biot.201700746
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- Publication type:
- Article
Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System.
- Published in:
- Biotechnology Journal, 2018, v. 13, n. 1, p. 1, doi. 10.1002/biot.201700335
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- Article
Cell culture efforts to reduce glycation in recombinant humanized antibody.
- Published in:
- 2006
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- Publication type:
- Abstract