We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Vinorelbine-based salvage therapy in HER2-positive metastatic breast cancer patients progressing during trastuzumab-containing regimens: a retrospective study.
- Authors
Montemurro F; Redana S; Nolè F; Donadio M; Jacomuzzzi ME; Valabrega G; Viale G; Sapino A; Aglietta M; Montemurro, Filippo; Redana, Stefania; Nolè, Franco; Donadio, Michela; Jacomuzzzi, Maria Elena; Valabrega, Giorgio; Viale, Giuseppe; Sapino, Anna; Aglietta, Massimo
- Abstract
<bold>Background: </bold>The vinka-alkaloyd vinorelbine is a potentially valuable treatment in patients with HER2-positive, trastuzumab-resistant advanced breast cancer. We sought to document the clinical activity of vinorelbine-based salvage treatments in this clinical setting.<bold>Methods: </bold>We analyzed a cohort of 424 consecutive women receiving trastuzumab-based therapy for HER2-positive advanced breast cancer. Of these, 299 were identified as progressing during the initial trastuzumab-based treatment, and 77 received vinorelbine-based therapy as first salvage treatment. Central review of pathological specimens revealed that 70 patients had HER2-amplification detected by FISH. For these patients we determined overall response rate (ORR = complete-CR + partial-PR) and clinical benefit (CB = CR+PR+ Stable disease lasting at least 6 months), time to progression (TTP) and overall survival (OS) from the initiation of vinorelbine-based salvage therapy.<bold>Results: </bold>In 60 patients who were evaluable for tumor response, ORR and CB rates were 28% (95% C.I. 18%-41%) and 50% (95% C.I. 38%-62%), respectively. Median follow-up from the initiation of salvage therapy was 15 months (range 1-63 months). Median TTP and OS were 7.1 months (95% C.I. 6.6-7.7 months) and 21 months (95% C.I. 14.3-27.7 months), respectively. No differences in clinical outcomes were observed according to whether vinorelbine was administered as a single agent or in combination with other cytostatics, or whether trastuzumab was stopped or continued beyond disease progression.<bold>Conclusion: </bold>our findings suggests that vinorelbine-based combinations are active and should be further evaluated in studies conducted in trastuzumab-resistant patients, including those evaluating newer HER2-targeting agents.
- Publication
BMC Cancer, 2008, Vol 8, p209
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/1471-2407-8-209