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- Title
Melanoma-related costs by disease stage and phase of management in Ireland.
- Authors
Crealey, Grainne E; Hackett, Caitriona; Harkin, Katharine; Heckmann, Patricia; Kelleher, Fergal; Lyng, Áine; McCarthy, Triona; McEnery, Maria; Meaney, Clare; Roche, Darren; Tobin, Anne-Marie
- Abstract
Background Management options for the treatment of melanoma have expanded in recent years. In an era of promising, but expensive novel pharmacological treatments, robust stage-specific melanoma-related cost estimates are necessary to support budgetary planning, evaluation of cost-effectiveness and to contribute to the investment case for prevention. Methods A detailed decision model, describing the melanoma care pathway (by disease stage) from diagnosis, through treatment and follow-up was developed over a 5-year time frame from the perspective of the Irish healthcare system. The model was populated with real-world data from the National Cancer Registry Ireland. Uncertainty was explored using one-way and probabilistic sensitivity analysis. Results The cost of managing a case of melanoma diagnosed at Stage IV (€122 985) was more than 25 times more expensive than managing a case diagnosed at Stage IA (€4269). Total costs were sensitive to the choice of immunotherapeutic and targeted drug, duration of treatment and proportion of patients receiving immunotherapy agents. Conclusions The rising incidence of melanoma and high cost of new novel therapies presents an immediate challenge to cancer control and public health globally. This study highlights the cost differential between early and late detection and the potential return on investment for prevention versus high-cost treatment.
- Subjects
IRELAND; TUMOR prevention; CONFIDENCE intervals; MELANOMA; MEDICAL care costs; PUBLIC health; TREATMENT duration; TUMOR classification; RESEARCH funding; COST effectiveness; SURVIVAL analysis (Biometry); IMMUNOTHERAPY
- Publication
Journal of Public Health, 2023, Vol 45, Issue 3, p714
- ISSN
1741-3842
- Publication type
Article
- DOI
10.1093/pubmed/fdac154