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- Title
Decoding mechanisms of diarrhea induction by enteric viruses.
- Authors
Hou, Gaopeng; Ding, Siyuan
- Abstract
This article discusses the mechanisms by which enteric viruses, such as rotavirus, norovirus, sapovirus, astrovirus, adenovirus, and poliovirus, induce diarrhea. The viruses disrupt intestinal homeostasis by infecting specific cells and causing structural changes, impairing nutrient absorption and leading to malabsorptive diarrhea. The enteric nervous system is also involved in diarrhea development, as viral infections activate serotonin secretion, leading to increased intestinal motility and fluid secretion. Viroporins, which are virally encoded proteins, play a role in manipulating cellular calcium signaling and facilitating viral replication, contributing to diarrhea. The article concludes by highlighting the importance of understanding these mechanisms for the development of antivirals and vaccines to reduce infection-associated diarrheal illness.
- Subjects
CYSTIC fibrosis transmembrane conductance regulator; VIRAL nonstructural proteins; VIRAL diarrhea; INTESTINAL physiology; CHLORIDE channels; ENTERIC nervous system; SEROTONIN
- Publication
PLoS Pathogens, 2024, Vol 20, Issue 8, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1012414