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- Title
Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes.
- Authors
BOTH, Peter; HÄBERLEIN, Hanns; GRESSNER, Axel Max; SIEG, Ina; DOSS, Manfred Otto
- Abstract
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Timedependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether. HL60 cells take up dimeric porphyrins in substantially higher quantities than hepatocytes do. These results allow the conclusion that physiological versus tumor cells behave differently with respect to porphyrin uptake: Whereas physiological cells prefer monomeric porphyrins, tumor cells preferentially incorporate dimeric porphyrins.
- Publication
Biological Chemistry, 1991, Vol 372, Issue 1, p69
- ISSN
1431-6730
- Publication type
Article