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- Title
Bioimaging of uranium and thorium in mice organs by laser ablation inductively coupled plasma mass spectrometry.
- Authors
Li, Xiaoyun; Wang, Xiaomei; Zhou, Jing; Li, Zi-Jian; Zhang, Linjuan; Wang, Jian-Qiang
- Abstract
The spatial distribution of thorium, uranium and other radioactive elements in biological tissues is significant for evaluating their migration, toxicity and possible decorporation mechanism, however, it is still a big challenge today for developing quantitative imaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) due to the lack of matrix matched standards for calibration. Herein, a fast and reliable LA-ICP-MS quantitative imaging method was developed by using gelatin plus standard solution to prepare a self-made reference material containing 100 μg/g of U and Th, overcoming the inhomogeneity of the raw animal tissue standard. Then the elemental spatial distribution of kidney and liver tissues from mice were revealed by using LA-ICP-MS method. The results showed that U accumulated mainly in the kidney and slightly in the liver, while most of Th was distributed in the liver and few of that in kidney. It was found that U and Th were heterogeneously distributed in kidney section while homogeneously distributed in liver section.
- Subjects
LASER ablation inductively coupled plasma mass spectrometry; THORIUM; URANIUM; RADIOACTIVE elements
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2023, Vol 332, Issue 7, p2559
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-023-08932-2