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- Title
Synthesis of H-Lys-Lys-Gly-OH Tripeptide and Study of Its Acute Toxicity.
- Authors
Popova, O. A.; Bunyatyan, N. D.; Bobizoda, G. M.; Samiev, M.; Prokof'ev, A. B.; Evteev, V. A.; Sernov, L. N.
- Abstract
Tripeptide H-Lys-Lys-Gly-OH was synthesized. Its toxic properties and biological activity were studied. The tripeptide was synthesized by extending the peptide chain from the C-terminus by synthesizing N2, N6-dicarbobenzoxylysine [N2,N6-(Cbz)2Lys] and N6-carbobenzoxylysine (N6-CbzLys) methyl ester hydrochloride and condensing them by the mixed anhydride method to produce the methyl ester of N2,N6-(Cbz)2Lys-N6-CbzLys. The next step in the tripeptide synthesis consisted of obtaining glycine benzyl ester (Gly-OBzl) hydrochloride and condensing it with N2,N6-(Cbz)2Lys-N6-CbzLys hydrazide to produce the protected target tripeptide Z-Lys(Z)-Lys-Gly-OBzl. The last step consisted of removing the protection using hydrogenolysis over Ni-Re catalyst. Test results showed that the synthesized tripeptide had low toxicity.
- Subjects
METHYL formate; GLYCINE; HYDROGENOLYSIS; CATALYSTS; ESTERS
- Publication
Pharmaceutical Chemistry Journal, 2020, Vol 54, Issue 9, p914
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-020-02296-7