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- Title
Synthesis and Anti-Inflammatory and Antiulcer Activity of a Glycyrrhizic Acid Conjugate with L-Phenylalanine Methyl Ester.
- Authors
Baltina, L. A.; Sapozhnikova, T. A.; Gabdrakhmanova, S. F.; Makara, N. S.; Kondratenko, R. M.; Zarudii, F. A.
- Abstract
A conjugate of glycyrrhizic acid (GA) with L-phenylalanine methyl ester was synthesized using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. Chemical modification of GA via addition of L-phenylalanine methyl ester moieties in the carbohydrate part of the glycoside was shown to form a marginally toxic compound with high anti-inflammatory activity in carrageenan- and formalin-induced mouse inflammation models and with pronounced antiulcer activity in rats. This was a significant advantage of this compound over known anti-inflammatory drugs.
- Subjects
METHYL formate; PHENYLALANINE; GLYCOSIDES; ANTI-inflammatory agents; CARBOHYDRATES
- Publication
Pharmaceutical Chemistry Journal, 2020, Vol 54, Issue 3, p225
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-020-02184-0