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- Title
Vitamin D Supplementation Effects in Patients with Heart Failure.
- Authors
Kerdegari, Maryam; Garacyaraghi, Mohammad; Siavash, Mansoor; Poormoghaddas, Ali
- Abstract
Background: Low vitamin D status may contribute to pathogenesis of congestive heart failure. We evaluated the effect of vitamin D supplementation on the left ventricular function and the NYHA Functional class of chronic heart failure patients. Methods: This double-blind, randomized, placebo-controlled trial was performed during Oct 2007 until Aug 2008 in Chamran and Noor Hospitals, Isfahan, Iran. One hundred and ten patients randomly received 50'000 IU vitamin D3/w plus 500 mg Ca/d [case group] or placebo plus 500 my Ca/d [control group] for 6 months. Biochemical variables, LVEF and NYHA Functional class status were assessed at baseline and after 6 months. Findings: Eighty two patients completed the study. Vitamin D supplementation increased the mean of25-Hydroxyvitamin D concentration by 33.9 ng/ml (P < 0.001); whereas placebo treatment was associated with an increase of only 6.2 ng/ml (P > 0.05). After 6 months treatment, the case and control groups showed improvement in left ventricular ejection fraction values and also left ventricular endsystolic volume; the extent of changes between two groups has significant difference (P < 0.05). The NYHA class improved in the case group but remained constant in the control group. Conclusion: Vitamin D3 improved left ventricular function and NYHA class in chronic heart failure (CHF) patients and might serve as a new agent for the future treatment of the disease.
- Subjects
ISFAHAN (Iran); IRAN; VITAMIN D in human nutrition; HEART failure patients; LEFT heart ventricle; RANDOMIZED controlled trials; CHOLECALCIFEROL
- Publication
Journal of Isfahan Medical School, 2010, Vol 28, Issue 109, p1
- ISSN
1027-7595
- Publication type
Article