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- Title
Evaluation of nafamostat mesilate as an alternative anticoagulant during intermittent hemodialysis in healthy Beagle dogs.
- Authors
Choi, Joon‐hyuk; Byun, Seok‐yeong; Nam, Aryung; Han, Sei‐myoung; Lee, Kyu‐pil; Song, Kun‐ho; Youn, Hwa‐young; Seo, Kyoung‐won
- Abstract
Abstract: Objective: To evaluate nafamostat mesilate (NM) as an alternative anticoagulant agent for intermittent hemodialysis (IHD). Design: Prospective randomized study. Setting: University teaching hospital. Animals: Eighteen healthy Beagle dogs. Interventions: In group 1 (<italic>n</italic> = 6), NM was administered at a dose of 0.5 mg/kg/h during IHD for 5 hours. In group 2 (<italic>n</italic> = 6), NM was administered at a low dose of 0.25 mg/kg/h during IHD. In group 3 (<italic>n</italic> = 6), which was the control group, unfractionated heparin (UFH) was administered during IHD. The evaluated parameters included: the amount of residual blood clots in the blood chamber and arterial side of the dialyzer; the levels of hemoglobin, hematocrit, and platelets; and the prothrombin time (PT), activated partial thromboplastin time (aPTT), and activated clotting time (ACT). Measurements and Main Results: Groups 1 and 2 successfully completed IHD without serious coagulation in the extracorporeal circulation. The residual blood clotting in the blood chamber and arterial side of the dialyzer did not significantly differ in groups 1 and 2 compared to group 3 (group 1 vs group 3, <italic>P</italic> = 1.000; and group 2 vs group 3, <italic>P</italic> = 1.000). No significant differences were observed between pre‐ and posttreatment PTs in groups 1 (<italic>P</italic> = 0.476) and 2 (<italic>P</italic> = 0.597), between pre‐ and posttreatment aPTTs in groups 1 (<italic>P</italic> = 0.983) and 2 (<italic>P</italic> = 0.977), and between pre‐ and posttreatment ACT in groups 1 (<italic>P</italic> = 0.282) and 2 (<italic>P</italic> = 0.401). In group 3, a significant elevation of ACT was observed at the posttest (<italic>P</italic> < 0.001). Conclusions: The results of this study in healthy Beagle dogs suggest that NM at 0.25 mg/kg/h may be a valid alternative to UFH for IHD. Further studies are needed in patients at high risk of bleeding.
- Subjects
ANTICOAGULANTS; SERINE proteinases; HEMODIALYSIS; DRUG administration; LABORATORY dogs
- Publication
Journal of Veterinary Emergency & Critical Care, 2018, Vol 28, Issue 2, p122
- ISSN
1479-3261
- Publication type
Article
- DOI
10.1111/vec.12696