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- Title
Spermine and Spermidine Detection through Restricted Intramolecular Rotations in a Tetraphenylethylene Derivative.
- Authors
Barros, Mariana; Ceballos, Samuel; Arroyo, Pau; Sáez, José Antonio; Parra, Margarita; Gil, Salvador; Costero, Ana María; Gaviña, Pablo
- Abstract
Biogenic polyamines, especially spermine and spermidine, are associated with cell growth and development. These amines can be found at high concentrations in the tumor cells, tissues, and urine of cancer patients. In contrast, spermidine levels drop with age, and a possible connection between low endogenous spermidine concentrations and age-related deterioration has been suggested. Thus, the quantification of these amines in body fluids like urine could be used in the diagnosis of different pathological situations. Here a new fluorescent molecular probe based on a tetraphenylethylene derivative is reported. This probe is able to selectively detect these amines through the enhancement of the fluorescence emission of the resulting complex. This fluorescence enhancement may be related to restricted intramolecular rotations of TPE phenyl rings induced by the analyte. Theoretical studies were carried out to shed light on the observed selectivity. Finally, the detection of these amines in urine was performed with limits of detection of 0.70 µM and 1.17 µM for spermine and spermidine, respectively.
- Subjects
SPERMIDINE; POLYAMINES; SPERMINE; TETRAPHENYLETHYLENE; MOLECULAR probes; FLUORESCENT probes
- Publication
Chemosensors, 2022, Vol 10, Issue 1, p8
- ISSN
2227-9040
- Publication type
Article
- DOI
10.3390/chemosensors10010008