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- Title
Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses.
- Authors
Tremblay, Joshua C.; Lovering, Andrew T.; Ainslie, Philip N.; Stembridge, Mike; Burgess, Keith R.; Bakker, Akke; Donnelly, Joseph; Lucas, Samuel J.E.; Lewis, Nia C.S.; Dominelli, Paolo B.; Henderson, William R.; Dominelli, Giulio S.; Sheel, A. William; Foster, Glen E.
- Abstract
Key points Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased by acute hypoxia during rest by unknown mechanisms., Oral administration of acetazolamide blunts the pulmonary vascular pressure response to acute hypoxia, thus permitting the observation of IPAVA blood flow with minimal pulmonary pressure change., Hypoxic pulmonary vasoconstriction was attenuated in humans following acetazolamide administration and partially restored with bicarbonate infusion, indicating that the effects of acetazolamide on hypoxic pulmonary vasoconstriction may involve an interaction between arterial pH and
- Subjects
BLOOD flow measurement; ARTERIOVENOUS anastomosis; HYPOXEMIA; ACETAZOLAMIDE; VASOCONSTRICTION
- Publication
Journal of Physiology, 2015, Vol 593, Issue 3, p723
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2014.282962