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- Title
Study of the association of resistance to two drugs in a transferable determinant in Salmonella typhimurium.
- Authors
Anderson, E. S.; Kelemen, Marianne V.; Jones, Christine M.; Pitton, J.-S.
- Abstract
A strain of S. typhimurium carrying transferable determinants, one for resistance to ampicillin (A), another for resistance to streptomycin and sulphonamides (SSu), was irradiated with ultraviolet light. A clone resulting from this treatment had lost streptomycin resistance and now carried the A determinant and a new determinant, ASu. Except for coding for ampicillin resistance, the ASu determinant was homologous with SSu. The A moiety of ASu produced ampicillin (penicillin) resistance of the same degree as the original A determinant. It was therefore concluded that irradiation had resulted in the elimination of the S gene in the SSu determinant and its replacement by an A gene to form ASu. Experiments with the ASu and SSu determinants suggest that there is normally only one copy of a resistance determinant in the host cell and only one cell site into which it can integrate.
- Publication
Genetics Research, 1968, Vol 11, Issue 1, p119
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300011265