We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acute cardiodepressant effects induced by bolus intravenous administration of amiodarone in rabbits.
- Authors
Lessa, Marcos Adriano; Tibiriçá, Eduardo
- Abstract
Amiodarone is a potent anti-arrhythmic with a large pharmacological spectrum that shares the mechanisms of action of all classes of anti-arrhythmic drugs. Originally used in the treatment of supraventricular arrhythmias, it has also been used to treat ventricular tachyarrhythmias. The recent inclusion of amiodarone in the Advanced Cardiac Life Support protocols warrants the characterization of the hemodynamic profile resulting from the rapid venous administration of the drug. Thus, the main purpose of the present study was to investigate the acute hemodynamic profile resulting from the bolus i.v. injection of amiodarone, compared with bolus i.v. administration of lidocaine. We investigated the acute hemodynamic effects of amiodarone and lidocaine, in an experimental model of open-chest pentobarbital-anesthetized rabbits (n = 24). Amiodarone (5 mg/kg) induced immediate reductions in mean arterial pressure (MAP) of 32 ± 5% (P < 0.001), accompanied by reductions in cardiac contractility and relaxation, as assessed by left ventricular (LV) +dP/dtmax and−dP/dtmax (40 ± 4 and 36 ± 4% respectively) (P < 0.001), heart rate (HR) 10 ± 1% (P < 0.05), cardiac output (CO) 24 ± 5% (P < 0.001) and systemic vascular resistance (SVR) 19 ± 3.5% (P < 0.05). Lidocaine (3 mg/kg) induced reductions in: MAP of 18 ± 7% (P < 0.001), LV +dP/dtmax and−dP/dtmax (40 ± 5 and 22 ± 7% respectively) (P < 0.001), HR 7 ± 1% (P < 0.01) and CO of 23 ± 6% (P < 0.001). SVR increased by 9 ± 1.5% (P > 0.05). It is concluded that rapid i.v. administration of both amiodarone and lidocaine induces significant cardiovascular depression mainly characterized by immediate reductions in cardiac contractility.
- Subjects
ARRHYTHMIA; LABORATORY rabbits; DRUG efficacy; AMIODARONE; LIDOCAINE; HEART diseases
- Publication
Fundamental & Clinical Pharmacology, 2005, Vol 19, Issue 2, p165
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/j.1472-8206.2004.00308.x