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- Title
The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells.
- Authors
Barrios, Evan L.; Leary, Jack R.; Darden, Dijoia B.; Rincon, Jaimar C.; Willis, Micah; Polcz, Valerie E.; Gillies, Gwendolyn S.; Munley, Jennifer A.; Dirain, Marvin L.; Ungaro, Ricardo; Nacionales, Dina C.; Gauthier, Marie-Pierre L.; Larson, Shawn D.; Morel, Laurence; Loftus, Tyler J.; Mohr, Alicia M.; Maile, Robert; Kladde, Michael P.; Mathews, Clayton E.; Brusko, Maigan A.
- Abstract
Introduction: Sepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who develop chronic critical illness. Methods: Cellular Indexing of Transcriptomes and Epitopes by Sequencing and transcriptomic analysis are used to describe MDSC subpopulations based on differential gene expression, RNA velocities, and biologic process clustering. Results: We identify a unique lineage and differentiation pathway for MDSCs after sepsis and describe a novel MDSC subpopulation. Additionally, we report that the heterogeneous response of the myeloid compartment of blood to sepsis is dependent on clinical outcome. Discussion: The origins and lineage of these MDSC subpopulations were previously assumed to be discrete and unidirectional; however, these cells exhibit a dynamic phenotype with considerable plasticity.
- Subjects
MYELOID-derived suppressor cells; PHENOTYPIC plasticity; GENE expression; MYELOID differentiation factor 88; CRITICALLY ill; CHRONIC diseases
- Publication
Frontiers in Immunology, 2024, p01
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1355405