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Cdk8 deletion in the Apc<sup>Min</sup> murine tumour model represses EZH2 activity and accelerates tumourigenesis.
Published in:
Journal of Pathology, 2015, v. 237, n. 4, p. 508, doi. 10.1002/path.4596
By:
- McCleland, Mark L;
- Soukup, Tim M;
- Liu, Scot D;
- Esensten, Jonathan H;
- de Sousa e Melo, Felipe;
- Yaylaoglu, Murat;
- Warming, Soren;
- Roose‐Girma, Merone;
- Firestein, Ron
Publication type:
Article
CK1ϵ Is Required for Breast Cancers Dependent on β- Catenin Activity.
Published in:
PLoS ONE, 2010, v. 5, n. 2, p. 1, doi. 10.1371/journal.pone.0008979
By:
- So Young Kim1,4,5,6;
- Dunn, Ian F.;
- Firestein, Ron;
- Gupta, Piyush;
- Wardwell, Leslie;
- Repich, Kara;
- Schinzel, Anna C.;
- Wittner, Ben;
- Silver, Serena J.;
- Root, David E.;
- Boehm, Jesse S.;
- Ramaswamy, Sridhar;
- Lander, Eric S.;
- Hahn, William C.
Publication type:
Article
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.
Published in:
PLoS ONE, 2008, v. 3, n. 4, p. 1, doi. 10.1371/journal.pone.0002020
By:
- Firestein, Ron;
- Blander, Gil;
- Michan, Shaday;
- Oberdoerffer, Philipp;
- Ogino, Shuji;
- Campbell, Jennifer;
- Bhimavarapu, Anupama;
- Luikenhuis, Sandra;
- de Cabo, Rafael;
- Fuchs, Charles;
- Hahn, William C.;
- Guarente, Leonard P.;
- Sinclair, David A.
Publication type:
Article
Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.
Published in:
Cancers, 2021, v. 13, n. 20, p. 5145, doi. 10.3390/cancers13205145
By:
- Chong, Wai C.;
- Jayasekara, W. Samantha N.;
- Vaghjiani, Vijesh G.;
- Parackal, Sarah;
- Sun, Claire;
- Popovski, Dean;
- Algar, Elizabeth M.;
- Firestein, Ron;
- Wood, Paul J.;
- Khan, Sara;
- Huang, Annie;
- Ashley, David M.;
- Downie, Peter;
- Cain, Jason E.
Publication type:
Article
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity.
Published in:
Nature, 2008, v. 455, n. 7212, p. 547, doi. 10.1038/nature07179
By:
- Firestein, Ron;
- Bass, Adam J.;
- So Young Kim;
- Dunn, Ian F.;
- Silver, Serena J.;
- Guney, Isil;
- Freed, Ellen;
- Ligon, Azra H.;
- Vena, Natalie;
- Ogino, Shuji;
- Chheda, Milan G.;
- Tamayo, Pablo;
- Finn, Stephen;
- Shrestha, Yashaswi;
- Boehm, Jesse S.;
- Jain, Supriya;
- Bojarski, Emeric;
- Mermel, Craig;
- Barretina, Jordi;
- Chan, Jennifer A.
Publication type:
Article
Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1270194
By:
- Ahmed, Afsar U.;
- Almasabi, Saleh;
- Firestein, Ron;
- Williams, Bryan R. G.
Publication type:
Article
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.
Published in:
2016
By:
- McCleland, Mark L.;
- Mesh, Kathryn;
- Lorenzana, Edward;
- Chopra, Vivek S.;
- Segal, Ehud;
- Watanabe, Colin;
- Haley, Benjamin;
- Mayba, Oleg;
- Yaylaoglu, Murat;
- Gnad, Florian;
- Firestein, Ron
Publication type:
journal article
Targeting LGR5<sup>+</sup> cells with an antibody-drug conjugate for the treatment of colon cancer.
Published in:
Science Translational Medicine, 2015, v. 7, n. 314, p. 1, doi. 10.1126/scitranslmed.aac7433
By:
- Junttila, Melissa R.;
- Weiguang Mao;
- Xi Wang;
- Bu-Er Wang;
- Thinh Pham;
- Flygare, John;
- Shang-Fan Yu;
- Sharon Yee;
- Goldenberg, David;
- Fields, Carter;
- Eastham-Anderson, Jeffrey;
- Singh, Mallika;
- Vij, Rajesh;
- Jo-Anne Hongo;
- Firestein, Ron;
- Schutten, Melissa;
- Flagella, Kelly;
- Polakis, Paul;
- Polson, Andrew G.
Publication type:
Article
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.
Published in:
Genome Biology, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s13059-023-03122-5
By:
- Voon, Hsiao P. J.;
- Hii, Linda;
- Garvie, Andrew;
- Udugama, Maheshi;
- Krug, Brian;
- Russo, Caterina;
- Chüeh, Anderly C.;
- Daly, Roger J.;
- Morey, Alison;
- Bell, Toby D. M.;
- Turner, Stephen J.;
- Rosenbluh, Joseph;
- Daniel, Paul;
- Firestein, Ron;
- Mann, Jeffrey R.;
- Collas, Philippe;
- Jabado, Nada;
- Wong, Lee H.
Publication type:
Article
Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.
Published in:
2024
By:
- Firestein, Ron;
- Blander, Gil;
- Michan, Shaday;
- Oberdoerffer, Philipp;
- Ogino, Shuji;
- Campbell, Jennifer;
- Bhimavarapu, Anupama;
- Luikenhuis, Sandra;
- de Cabo, Rafael;
- Fuchs, Charles;
- Hahn, William C.;
- Guarente, Leonard P.;
- Sinclair, David A.
Publication type:
Correction Notice
Rb targets histone H3 methylation and HP1 to promoters.
Published in:
Nature, 2001, v. 412, n. 6846, p. 561, doi. 10.1038/35087620
By:
- Nielsen, Soren J.;
- Schneider, Robert;
- Bauer, Uta-Maria;
- Bannister, Andrew J.;
- Morrison, Ashby;
- O'Carroll, Donal;
- Firestein, Ron;
- Cleary, Michael;
- Jenuwein, Thomas;
- Herrera, Rafael E.;
- Kouzarides, Tony
Publication type:
Article
The Landscape of Pediatric High-Grade Gliomas: The Virtues and Pitfalls of Pre-Clinical Models.
Published in:
Biology (2079-7737), 2024, v. 13, n. 6, p. 424, doi. 10.3390/biology13060424
By:
- Furst, Liam M.;
- Roussel, Enola M.;
- Leung, Ryan F.;
- George, Ankita M.;
- Best, Sarah A.;
- Whittle, James R.;
- Firestein, Ron;
- Faux, Maree C.;
- Eisenstat, David D.
Publication type:
Article
CDK8 expression in 470 colorectal cancers in relation to β-catenin activation, other molecular alterations and patient survival.
Published in:
International Journal of Cancer, 2010, v. 126, n. 12, p. 2863, doi. 10.1002/ijc.24908
By:
- Firestein, Ron;
- Shima, Kaori;
- Nosho, Katsuhiko;
- Irahara, Natsumi;
- Baba, Yoshifumi;
- Bojarski, Emeric;
- Giovannucci, Edward L.;
- Hahn, William C.;
- Fuchs, Charles S.;
- Ogino, Shuji
Publication type:
Article
Emerging and Biological Concepts in Pediatric High-Grade Gliomas.
Published in:
Cells (2073-4409), 2024, v. 13, n. 17, p. 1492, doi. 10.3390/cells13171492
By:
- Yoel, Abigail;
- Adjumain, Shazia;
- Liang, Yuqing;
- Daniel, Paul;
- Firestein, Ron;
- Tsui, Vanessa
Publication type:
Article
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer.
Published in:
Cells (2073-4409), 2020, v. 9, n. 9, p. 2125, doi. 10.3390/cells9092125
By:
- Bian, Jia;
- Dannappel, Marius;
- Wan, Chunhua;
- Firestein, Ron
Publication type:
Article
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.
Published in:
British Journal of Pharmacology, 2013, v. 168, n. 2, p. 445, doi. 10.1111/j.1476-5381.2012.02138.x
By:
- Boswell, C Andrew;
- Mundo, Eduardo E;
- Firestein, Ron;
- Zhang, Crystal;
- Mao, Weiguang;
- Gill, Herman;
- Young, Cynthia;
- Ljumanovic, Nina;
- Stainton, Shannon;
- Ulufatu, Sheila;
- Fourie, Aimee;
- Kozak, Katherine R;
- Fuji, Reina;
- Polakis, Paul;
- Khawli, Leslie A;
- Lin, Kedan
Publication type:
Article
PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03494-4
By:
- Raab, Monika;
- Sanhaji, Mourad;
- Matthess, Yves;
- Hörlin, Albrecht;
- Lorenz, Ioana;
- Dötsch, Christina;
- Habbe, Nils;
- Waidmann, Oliver;
- Kurunci-Csacsko, Elisabeth;
- Firestein, Ron;
- Becker, Sven;
- Strebhardt, Klaus
Publication type:
Article
Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids.
Published in:
Nanotechnology, Science & Applications, 2021, v. 14, p. 139, doi. 10.2147/NSA.S321725
By:
- Firestein, Ron;
- Marcinkiewicz, Cezary;
- Nie, Linyan;
- Chua, Hui Kheng;
- Quesada, Ines Velazquez;
- Torelli, Marco;
- Sternberg, Mark;
- Gligorijevic, Bojana;
- Shenderova, Olga;
- Schirhagl, Romana;
- Feuerstein, Giora Z
Publication type:
Article

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