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- Title
Clinical features and successful recovery from disseminated nocardiosis after BMT.
- Authors
Machado, C M; Macedo, M C; Castelli, J B; Ostronoff, M; Silva, A C; Zambon, E; Massumoto, C; Chamone, D F; Dulley, F L
- Abstract
Nocardiosis has rarely been described after BMT. When the doses of immunosuppressive therapy were tapered, a 46-year-old BMT recipient developed chronic graft-versus-host disease (GVHD) and immunosuppressive drugs were increased. Sixteen days later the patient developed nocardiosis diagnosed by lung biopsy. Trimethoprim/sulfamethoxazole (TMP/SMZ) was initiated but the doses were reduced because of rising creatinine levels. Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased. After 4 months, the brain lesion was unaltered despite resolution of pulmonary lesions. Clinical improvement was observed after drainage of the brain abscess.
- Subjects
NOCARDIA; BONE marrow transplantation
- Publication
Bone Marrow Transplantation, 1997, Vol 19, Issue 1, p81
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1700616