We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer.
- Authors
Yonsoo Kim; Young Min Kim; Jie-Hyun Kim; Young Hoon Youn; Jong Won Kim; Hyojin Park
- Abstract
Background/Aims Although prolonged post-operative ileus (PPOI) is an important factor for the prolonged length of post-operative hospital stay, there is still a lack of effective predictive and therapeutic methods for PPOI. Previous studies reported that increased inflammatory markers, such as C-reactive protein (CRP) level and neutrophil to lymphocyte ratio (NLR), are associated with malignancies. The aim of our study is to elucidate the association between peri-operative inflammatory markers and PPOI after gastrectomy for gastric cancer. Methods We enrolled patients who received gastrectomy for gastric cancer from June 2013 to January 2016 at a single tertiary referral center in Seoul, Korea. We evaluated peri-operative inflammatory markers, including CRP level, NLR, and platelet to lymphocyte ratio (PLR) of enrolled patients. We compared these data between control group and PPOI group. Results A total of 390 subjects were enrolled in this study, and 132 patients (33.8%) showed PPOI. In univariate analysis, preoperative CRP level and NLR, post-operative day (POD) 1 CRP level, NLR, and PLR, and POD3 CRP level, NLR, and PLR were significantly associated with PPOI. In multivariate analysis, preoperative NLR ( P = 0.014), POD1 NLR ( P = 0.019), POD3 CRP ( P = 0.004), and POD3 NLR ( P = 0.008) were independent risk factors for PPOI. Conclusions Peri-operative inflammatory markers, such as CRP level and NLR, are useful predictive factors for PPOI who received gastrectomy for gastric cancer. Moreover, prophylactic antibiotics and anti-inflammatory drugs can be preventive and therapeutic agents for PPOI.
- Subjects
SEOUL (Korea); STOMACH cancer; NEUTROPHIL lymphocyte ratio; GASTRECTOMY; C-reactive protein; BOWEL obstructions
- Publication
Journal of Neurogastroenterology & Motility, 2021, Vol 27, Issue 4, p588
- ISSN
2093-0879
- Publication type
Article
- DOI
10.5056/jnm20203