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- Title
Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
- Authors
Kaitu'u-Lino, Tu'uhevaha J.; MacDonald, Teresa M.; Cannon, Ping; Nguyen, Tuong-Vi; Hiscock, Richard J.; Haan, Nick; Myers, Jenny E.; Hastie, Roxanne; Dane, Kirsten M.; Middleton, Anna L.; Bittar, Intissar; Sferruzzi-Perri, Amanda N.; Pritchard, Natasha; Harper, Alesia; Hannan, Natalie J.; Kyritsis, Valerie; Crinis, Nick; Hui, Lisa; Walker, Susan P.; Tong, Stephen
- Abstract
Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks' gestation and low birthweight, an indicator of placental insufficiency. We generate a 4-tier risk model based on SPINT1 concentrations, where the highest risk tier has approximately a 2-5 fold risk of birthing neonates with birthweights under the 3rd, 5th, 10th and 20th centiles, whereas the lowest risk tier has a 0-0.3 fold risk. Low SPINT1 is associated with antenatal ultrasound and neonatal anthropomorphic indicators of placental insufficiency. We validate the association between low circulating SPINT1 and placental insufficiency in two other cohorts. Low circulating SPINT1 is a marker of placental insufficiency and may identify pregnancies with an elevated risk of stillbirth. There are no reliable tests for placental insufficiency, which can lead to fetal growth restriction and stillbirth. Here the authors demonstrate that low levels of circulating SPINT1 are associated to low birthweight, and several ultrasound and neonatal anthropomorphic indicators of placental insufficiency.
- Subjects
FETAL development; PLACENTAL growth factor; SERINE proteinase inhibitors; PREGNANCY; STILLBIRTH; BIRTH weight; PEPTIDASE; NEWBORN infants
- Publication
Nature Communications, 2020, Vol 11, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-16346-x