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Heterogeneity of Alzheimer's disease: consequence for drug trials?
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0455-y
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- Publication type:
- Article
A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0448-x
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- Article
The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0382-y
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- Publication type:
- Article
Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI).
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0444-1
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- Article
Correction to: The Toronto cognitive assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment.
- Published in:
- 2018
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- Publication type:
- Correction Notice
Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer's disease: a network meta-analysis of 41 randomized controlled trials.
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0457-9
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- Publication type:
- Article
Reactions to learning a "not elevated" amyloid PET result in a preclinical Alzheimer's disease trial.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0452-1
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- Article
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0451-2
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- Article
Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0449-9
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- Publication type:
- Article
SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA).
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0447-y
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- Publication type:
- Article
Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0445-0
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- Article
Insights into globalization: comparison of patient characteristics and disease progression among geographic regions in a multinational Alzheimer's disease clinical program.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0443-2
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- Publication type:
- Article
Active full-length DNA Aβ<sub>42</sub> immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0441-4
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- Article
Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0440-5
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- Article
Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0433-4
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- Article
The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0432-5
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- Publication type:
- Article
MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0428-1
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- Article
Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0376-9
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- Publication type:
- Article
Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia?.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0430-7
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- Article
Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's disease.
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0439-y
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- Publication type:
- Article
Secondary prevention of Alzheimer's dementia: neuroimaging contributions.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0438-z
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- Publication type:
- Article
Analysis of the risk and risk factors for injury in people with and without dementia: a 14-year, retrospective, matched cohort study.
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0437-0
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- Article
Variability in metabolic parameters and risk of dementia: a nationwide population-based study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0442-3
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- Article
Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0434-3
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- Article
FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0436-1
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- Article
Exome sequencing in an Italian family with Alzheimer's disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615H.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0435-2
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- Article
Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0431-6
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- Article
Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY).
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0427-2
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- Article
Correction to: A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.
- Published in:
- 2018
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- Publication type:
- Correction Notice
Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0426-3
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- Publication type:
- Article
"Exceptional brain aging" without Alzheimer's disease: triggers, accelerators, and the net sum game.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0373-z
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- Publication type:
- Article
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0377-8
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- Article
Study partners: essential collaborators in discovering treatments for Alzheimer's disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0425-4
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- Publication type:
- Article
Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0429-0
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- Article
Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0418-3
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- Publication type:
- Article
Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0422-7
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- Publication type:
- Article
Sex ratio in dementia with Lewy bodies balanced between Alzheimer’s disease and Parkinson’s disease dementia: a cross-sectional study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0417-4
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- Publication type:
- Article
The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0423-6
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- Publication type:
- Article
Patterns of cognitive function in middle-aged and elderly Chinese adults—findings from the EMCOA study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0421-8
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- Publication type:
- Article
Is intracranial volume a suitable proxy for brain reserve?
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0408-5
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- Publication type:
- Article
Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0419-2
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- Article
Cognitive composite score association with Alzheimer’s disease plaque and tangle pathology.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0401-z
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- Publication type:
- Article
Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer’s disease: a longitudinal cohort study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0420-9
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- Publication type:
- Article
Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0394-7
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- Publication type:
- Article
White matter microstructure is altered in cognitively normal middle-aged <italic>APOE</italic>-ε4 homozygotes.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0375-x
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- Publication type:
- Article
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0410-y
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- Publication type:
- Article
Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0415-6
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- Publication type:
- Article
Synergistic interaction between APOE and family history of Alzheimer’s disease on cerebral amyloid deposition and glucose metabolism.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0411-x
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- Publication type:
- Article
Apathy is associated with faster global cognitive decline and early nursing home admission in dementia with Lewy bodies.
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- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0416-5
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- Publication type:
- Article
Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer’s disease.
- Published in:
- Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0413-8
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- Publication type:
- Article