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- Title
Clinical Characteristics Risk Factors Associated With Fungal Infections Among Preterm Infants.
- Authors
Van Dem, Pham; Mai, Dinh Thi Phuong; Giang, Nguyen Thuy; Thoi, Vu Huu; Anh, Do Tuan; Hao, Cao Thi Bich; Mai, Pham Thi; Linh, Le Dieu; Tam, Ngo Thi; Nam, Nguyen Thanh
- Abstract
Objectives: To examine clinical characteristics and factors associated with fungal blood infection among preterm neonates in a tertiary hospital in Vietnam. Methods: A case-control study of 32 preterm neonates with fungal infection (cases) and 303 preterm infants without fungal infection (controls) were treated at the Neonatal Intensive Care Unit of the Pediatrics Department, Bach Mai Hospital, in 2019. Clinical and laboratory characteristics were collected. Multivariate logistic regression was used to identify factors associated with fungal infection. Results: The rate of fungal infection was highest in very preterm infants (62.3%) and those had very low birth weight (60.9%). Among infants with invasive fungal infections, the most common fungus in the study was Candida albicans (56.5%), followed by Candida tropicalis (21.7%) and Candida parrapsilosis (8.7%). In addition, invasive fungal infections in preterm infants were associated with central venous catheterization (odds ratio [OR] = 10.2, 95% confidence interval [CI] = 2.5-41.9), anoxia (OR = 12.2, 95% CI = 2.8-53.1), and thrombocytopenia (OR = 4.4, 95% CI = 1.6-12.4). Conclusion: Premature babies with invasive fungal infections are mostly very preterm or extremely preterm and have very low birth weight or extremely low birth weights. In addition, children with specific problems such as having a central venous catheter, hypoxia, and thrombocytopenia have a higher risk of fungal infections. These results suggest that appropriate measures are needed to reduce fungal infections and the dangers of fungal infections in this population.
- Subjects
VIETNAM; NEONATAL intensive care; CONFIDENCE intervals; MULTIVARIATE analysis; CENTRAL venous catheterization; TERTIARY care; CASE-control method; NEONATAL intensive care units; VERY low birth weight; SYMPTOMS; MYCOSES; DESCRIPTIVE statistics; LOGISTIC regression analysis; CANDIDA albicans; ODDS ratio; THROMBOCYTOPENIA; HYPOXEMIA; DISEASE complications; CHILDREN
- Publication
Journal of Neonatology, 2023, Vol 37, Issue 1, p59
- ISSN
0973-2179
- Publication type
Article
- DOI
10.1177/09732179231157199