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- Title
Managing potential drug-drug interactions between gastric acid-reducing agents and antiretroviral therapy: experience from a large HIV-positive cohort.
- Authors
Lewis, J. M.; Stott, K. E.; Monnery, D.; Seden, K.; Beeching, N. J.; Chaponda, M.; Khoo, S.; Beadsworth, M. B. J.
- Abstract
Drug-drug interactions between antiretroviral therapy and other drugs are well described. Gastric acid-reducing agents are one such class. However, few data exist regarding the frequency of and indications for prescription, nor risk assessment in the setting of an HIV cohort receiving antiretroviral therapy. To assess prevalence of prescription of gastric acid-reducing agents and drug-drug interaction within a UK HIV cohort, we reviewed patient records for the whole cohort, assessing demographic data, frequency and reason for prescription of gastric acid-reducing therapy. Furthermore, we noted potential drug-drug interaction and whether risk had been documented and mitigated. Of 701 patients on antiretroviral therapy, 67 (9.6%) were prescribed gastric acid-reducing therapy. Of these, the majority (59/67 [88.1%]) were prescribed proton pump inhibitors. We identified four potential drug-drug interactions, which were appropriately managed by temporally separating the administration of gastric acid-reducing agent and antiretroviral therapy, and all four of these patients remained virally suppressed. Gastric acid-reducing therapy, in particular proton pump inhibitor therapy, appears common in patients prescribed antiretroviral therapy. Whilst there remains a paucity of published data, our findings are comparable to those in other European cohorts. Pharmacovigilance of drug-drug interactions in HIV-positive patients is vital. Education of patients and staff, and accurate data-gathering tools, will enhance patient safety.
- Subjects
DRUG interactions; ANTIRETROVIRAL agents; GASTRIC acid; HIV infection risk factors; DEMOGRAPHIC databases; PROTON pump inhibitors; HIV infection epidemiology; ANTACIDS; HIV infections; MEDICAL prescriptions; HIGHLY active antiretroviral therapy; DISEASE prevalence; HIV protease inhibitors; THERAPEUTICS
- Publication
International Journal of STD & AIDS, 2016, Vol 27, Issue 2, p105
- ISSN
0956-4624
- Publication type
journal article
- DOI
10.1177/0956462415574632