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- Title
Positive Association between C-159T Functional Gene Polymorphism and Allergic Rhinitis.
- Authors
Marzoni, Hadi Zare; Mohammadi, Mojgan; Azad, Farahzad Jabbari; Hosseini, Reza Farid; Khoshkhoi, Maryam; Tavakolafshari, Jalil
- Abstract
Objective: Allergic rhinitis is an inflammatory disease of the nasal mucosa. It is the most common allergic disease with a prevalence rate of 15 to 20 percent. According to the recent studies the Serum levels of CD14 is correlated to IgE- dependent response and inflammatory phenotypes in allergic patients. On the other hand, a functional polymorphism named C-159T in the Promoter of CD14 gene is associated with the serum level of CD14. The aim of this study was the investigation on the relationship between C-159T in the CD14 promoter gene in patients with allergic rhinitis. Material and Methods: Seventy-five patients with allergic rhinitis who referred to the Ghaem Hospital, Mashhad University of Medical Sciences and 75 healthy controls from the national blood center were enrolled in this study. The samples were collected randomly and the range of Age was between 18 to 60 years old in both groups. Any Participants with any other diseases were excluded. The detection of C-159T polymorphism in the CD14 promotor gene was performed by PCR-RFLP method. After collecting data, the results were analyzed by spss16 software. Results: According to this study, the mean age of case control groups were 30.04 ± 9.41 and 35.32 ± 8.63, respectively. The CD14 gene polymorphism frequency in the case group was 6.7%, 81.3% and 12% for the CC, the CT and the TT genotypes, respectively. Additionally, the genotype frequency of the CC, the CT and the TT were 46.7%, 46.7% and 6.7%, respectively in the control group. The results showed that a significant association between C-159T gene polymorphism and allergic rhinitis (p<0.001). The results of statistical analysis showed that TT genotype increased the risk of allergic rhinitis (p<0.001, OR, 12.6; CI95%, 2.98- 53.17). Conclusion: The results of this study showed that the functional polymorphism C- 159T in the CD14 Promoter gene is one of the effective factors for the development of allergic rhinitis disease. These results might be useful for prediction of the allergic rhinitis.
- Subjects
IMMUNE system; GENETIC polymorphisms
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p98
- ISSN
1735-1502
- Publication type
Abstract