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- Title
Haplotype approach for association analysis on hypertension.
- Authors
Xiaowei Shen; Espin-Garcia, Osvaldo; Xin Qiu; Brhane, Yonathan; Liu, Geoffrey; Wei Xu
- Abstract
We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also conducted for the whole chromosome 3. We found 1 block from the ULK4 gene and 2 blocks from the LOC64690 gene that were significantly associated with hypertension.
- Subjects
HAPLOTYPES; HYPERTENSION genetics; GENETIC databases; SINGLE nucleotide polymorphisms; CHROMOSOMES
- Publication
BMC Proceedings, 2014, Vol 9, Issue Supplement 5, p1
- ISSN
1753-6561
- Publication type
Article
- DOI
10.1186/1753-6561-8-S1-S57