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- Title
Effects of Selenium-Enriched Probiotics on Heart Lesions by Influencing the mRNA Expressions of Selenoproteins and Heat Shock Proteins in Heat Stressed Broiler Chickens.
- Authors
Khan, Alam Zeb; Kumbhar, Shahnawaz; Hamid, Muhammad; Afzal, Samreen; Parveen, Fahmida; Yunhuan Liu; Hao Shu; Mengistu, Berhe Mekonnen; Kehe Huang
- Abstract
Selenium is one of the most vital trace elements regulating various body functions. Herein, we observe the effects of selenium-enriched probiotics on heart lesion in broiler chickens under high ambient temperature and explore the underlying mechanisms. Four different groups of broiler chickens were fed a corn-soybean basal diet having no Se supplementation (Con group), basal diet with the addition of probiotics (P group), a basal diet with Se supplementation in the form of sodium selenite (SS group, 0.30mg Se/kg) and basal diet with the addition of selenium enriched probiotics (SP group, 0.30mg Se/kg). The results showed that P, SS, or SP supplementation significantly (P<0.05) up-regulated mRNA expression of selenoproteins (GPx1, GPx4) and down-regulated heat shock proteins (Hsp60, Hsp70 and Hsp90) in heart as compared to Con, P and SS diets. Herein, we suggest that SP product can serve as a feasible nutritive supplement, capable of protecting the heart from toxic effect of oxidative stress in summer season.
- Subjects
MESSENGER RNA; GENE expression; SELENOPROTEINS; HEAT shock proteins; PROBIOTICS; HEART injuries; CHICKEN diseases
- Publication
Pakistan Veterinary Journal, 2016, Vol 36, Issue 4, p460
- ISSN
0253-8318
- Publication type
Article