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- Title
Ligand-dependent activation of ERβ lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats.
- Authors
Jazbutyte, Virginija; Arias-Loza, Paula Anahi; Kai Hu; Widder, Julian; Govindaraj, Vijayakumar; von Poser-Klein, Christine; Bauersachs, Johann; Fritzemeier, Karl-Heinrich; Hegele-Hartung, Christa; Neyses, Ludwig; Ertl, Georg; Pelzer, Theo
- Abstract
Aims: The biological effects of oestrogens are mediated by two different oestrogen receptor (ER) subtypes, ERα and ERβ, which might play different, redundant, or opposing roles in cardiovascular disease. Previously, we have shown that the selective ERα agonist 16α-LE2 improves vascular relaxation, attenuates cardiac hypertrophy, and increases cardiac output without lowering elevated blood pressure in spontaneously hypertensive rats (SHR). Because ERβ-deficient mice exhibit elevated blood pressure and since the ERβ agonist 8β-VE2 attenuated hypertension in aldosterone-salt-treated rats, we have now tested the hypothesis that the isotype-selective ERβ agonist 8β-VE2 might be capable of lowering elevated blood pressure in ovariectomized SHR.
- Subjects
ESTROGEN receptors; CARDIOVASCULAR diseases; CARDIAC hypertrophy; HYPERTENSION; ANIMAL models in research; BLOOD pressure; LABORATORY rats
- Publication
Cardiovascular Research, 2008, Vol 77, Issue 4, p774
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvm081