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- Title
Timeâfrequency analysis reveals decreased high-frequency oscillations in writer's cramp.
- Authors
Zoé Cimatti; Denis P Schwartz; Frédéric Bourdain; Sabine Meunier; Jean-Pierre Bleton; Marie Vidailhet; Bernard Renault; Line Garnero
- Abstract
High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with timeâfrequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.
- Subjects
NEURONS; DYSTONIA; NEURAL stimulation; BRAIN
- Publication
Brain: A Journal of Neurology, 2007, Vol 130, Issue 1, p198
- ISSN
0006-8950
- Publication type
Article