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- Title
Galectin-1 Accelerates Wound Healing by Regulating the Neuropilin-1/Smad3/NOX4 Pathway and ROS Production in Myofibroblasts.
- Authors
Lin, Yueh-Te; Chen, Jhih-Sian; Wu, Ming-Heng; Hsieh, I-Shan; Liang, Chen-Hsien; Hsu, Cheng-Lung; Hong, Tse-Ming; Chen, Yuh-Ling
- Abstract
Myofibroblasts have a key role in wound healing by secreting growth factors and chemoattractants to create new substrates and proteins in the extracellular matrix. We have found that galectin-1, a β-galactose-binding lectin involved in many physiological functions, induces myofibroblast activation; however, the mechanism remains unclear. Here, we reveal that galectin-1-null (Lgals1−/−) mice exhibited a delayed cutaneous wound healing response. Galectin-1 induced myofibroblast activation, migration, and proliferation by triggering intracellular reactive oxygen species (ROS) production. A ROS-producing protein, NADPH oxidase 4 (NOX4), was upregulated by galectin-1 through the neuropilin-1/Smad3 signaling pathway in myofibroblasts. Subcutaneous injection of galectin-1 into wound areas accelerated the healing of general and pathological (streptozotocin-induced diabetes mellitus) wounds and decreased the mortality of diabetic mice with skin wounds. These findings indicate that galectin-1 is a key regulator of wound repair that has therapeutic potential for pathological or imperfect wound healing.
- Subjects
GALECTINS; WOUND care; BIOCHEMICAL substrates; MYOFIBROBLASTS; THERAPEUTICS; DIABETES complications; LABORATORY mice
- Publication
Journal of Investigative Dermatology, 2015, Vol 135, Issue 1, p258
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2014.288