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- Title
Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan.
- Authors
Chong, G.; Dickson, J. L. B.; Cunningham, D.; Norman, A. R.; Rao, S.; Hill, M. E.; Price, T. J.; Oates, J.; Tebbutt, N.
- Abstract
Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-refractory disease. Eligible patients with progressive disease during or within 6 months of second-line chemotherapy were treated with capecitabine (1250 mg m(-2) twice daily) days 1-14 every 3 weeks and MMC (7 mg m(-2) IV bolus) once every 6 weeks. A total of 36 patients were recruited, with a median age of 64 years (range 40-77), and 23 patients (78%) were performance status 0-1. The objective response rate was 15.2%. In all, 48.5% of patients had stable disease. Median failure-free survival was 5.4 months (95% CI 4.6-6.2). Median overall survival was 9.3 months (95% CI: 6.9-11.7). Grade 3 toxicities were palmar-plantar erythema 16.7%, vomiting 8.3%, diarrhoea 2.8%, anaemia 8.3%, and neutropenia 2.8%. No patients developed haemolytic uraemic syndrome. Symptomatic improvement occurred for pain, bowel symptoms, and dyspnoea. Capecitabine in combination with MMC is an effective regimen for metastatic colorectal cancer resistant to 5FU and irinotecan with an acceptable toxicity profile and a convenient administration schedule.
- Subjects
COLON cancer; METASTASIS; CANCER invasiveness; CANCER patients; MITOMYCIN C; FLUOROURACIL; ANTINEOPLASTIC antibiotics; ANTINEOPLASTIC agents; CAMPTOTHECIN; CLINICAL trials; COLON tumors; COMPARATIVE studies; DRUG resistance in cancer cells; RESEARCH methodology; MEDICAL cooperation; RECTUM tumors; RESEARCH; SURVIVAL; EVALUATION research; TREATMENT effectiveness; SALVAGE therapy; DEOXYCYTIDINE; MITOMYCINS; THERAPEUTICS
- Publication
British Journal of Cancer, 2005, Vol 93, Issue 5, p510
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6602733