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- Title
Postacute symptoms 4 months after SARS-CoV-2 infection during the Omicron period: a nationwide Danish questionnaire study.
- Authors
Spiliopoulos, Lampros; Sørensen, Anna Irene Vedel; Bager, Peter; Nielsen, Nete Munk; Hansen, Jørgen Vinsløv; Koch, Anders; Meder, Inger Kristine; Videbech, Poul; Ethelberg, Steen; Hviid, Anders
- Abstract
Postacute symptoms are not uncommon after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with pre-Omicron variants. How the Omicron variant and coronavirus disease 2019 (COVID-19) booster vaccination influence the risk of postacute symptoms is less clear. We analyzed data from a nationwide Danish questionnaire study, EFTER-COVID, comprising 36 109 individuals aged ≥15 years who were tested between July 2021 and January 2022, to evaluate the associations of the Omicron variant and COVID-19 booster vaccination with postacute symptoms and new-onset general health problems 4 months after infection with SARS-CoV-2. Risk differences (RDs) were estimated by comparing Omicron cases with controls, comparing Omicron cases with Delta cases, and comparing Omicron cases vaccinated with 3 doses with those vaccinated with 2 doses, adjusting for age, sex, body mass index, self-reported chronic diseases, Charlson comorbidity index, health-care occupation, and vaccination status. Four months after testing for SARS-CoV-2 during the Omicron period, cases experienced substantial postacute symptoms and new-onset health problems in comparison with controls; the largest RD was observed for memory issues (RD = 7.4%; 95% CI, 6.4-8.3). However, risks were generally lower than those in the Delta period, particularly for dysosmia (RD = –15.0%; 95% CI, −17.0 to −13.2) and dysgeusia (RD = –11.2%; 95% CI, −13.2 to −9.5). Booster vaccination was associated with fewer postacute symptoms and new-onset health problems 4 months after Omicron infection as compared with 2 doses of COVID-19 vaccine.
- Subjects
IMMUNIZATION; RESEARCH funding; POST-acute COVID-19 syndrome; QUESTIONNAIRES; TASTE disorders; AGE factors in disease; MEMORY; GENETIC mutation; CONFIDENCE intervals; COVID-19; VACCINATION status; TIME
- Publication
American Journal of Epidemiology, 2024, Vol 193, Issue 8, p1106
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwad225