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- Title
Reactions of organolithium reagents with quinazoline derivatives.
- Authors
El-Hiti, Gamal A.; Hegazy, Amany S.; Alotaibi, Mohammad Hayal; Ajarim, Mansour D.
- Abstract
This review deals with directed and regioselective lithiation of various quinazoline derivatives by the use of alkyllithiums in anhydrous THF at low temperature. Reactions of the lithium reagents obtained from the lithiation reactions with a range of electrophiles give the corresponding substituted derivatives in high yields. The procedures are simple, efficient and general to provide derivatives which might be difficult to produce by other means. In some cases nucleophilic addition of alkyllithiums takes place to produce the corresponding addition products via 1,2- and 3,4-additions. In other cases nucleophilic substitution or halogen-lithium exchange reactions occur.
- Subjects
CHEMICAL reactions; ORGANOLITHIUM compounds; QUINAZOLINE; CHEMICAL derivatives; REGIOSELECTIVITY (Chemistry); LITHIATION; ELECTROPHILES; NUCLEOPHILIC addition (Chemistry)
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2012, p35
- ISSN
1551-7004
- Publication type
Article