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- Title
Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation.
- Authors
Pecora Liberman, Patricia; Schultz, Christiane; Schmidt Goffi-Gómez, María; Antoneli, Célia; Motoro Chojniak, Martha; Novaes, Paulo
- Abstract
Background: The objective of this study was to identify the ocurrence of hearing loss in children treated for retinoblastoma using a multidisciplinary approach. Patients and methods: Thirty-two children were evaluated pre- and post-treatment. Eleven children were treated exclusively with enucleation, fifteen with carboplatin and six with cisplatin. Otoacoustic emissions were performed with the ILO 88, before and after the treatment. Results: In our study we found 5 children (24%) with hearing loss among the 21 evaluated. However in the group of children treated with carboplatin ( N=15), 1 case (6.6%) presented hearing loss, while among those treated with cisplatin ( N=6) we found 4 cases (66.6%) with hearing loss ( p=0.0114). Conclusion: We concluded that patients who are treated with cisplatin are at risk for developing hearing loss.
- Publication
Clinical & Translational Oncology, 2011, Vol 13, Issue 5, p348
- ISSN
1699-048X
- Publication type
Article
- DOI
10.1007/s12094-011-0665-2