We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Carbohydrate-induced modulation of cell membrane. VIII. Agglutination with mammalian lectin galectin-1 increases osmofragility and membrane fluidity of trypsinized erythrocytes
- Authors
Gupta, Rajesh K.; Pande, Abhay H.; Gulla, Krishana C.; Gabius, Hans-J.; Hajela, Krishnan
- Abstract
Abstract: Interaction of lectins with cell surface determinants may alter membrane properties. Using trypsinized rabbit erythrocytes as model we tested the capacity of an endogenous lectin in this respect. Galectin-1 is a member of an adhesion/growth-regulatory family known to interact for example with ganglioside GM1 and also the hydrophobic tail of oncogenic H-Ras. Assays on membrane fluidity and osmofragility detect galectin-1’s capacity to increase the parameters. Moreover, it increases susceptibility of erythrocytes to radical damage. These observations indicate the potential of this endogenous lectin to affect membrane properties beyond the immediate interaction with cell surface epitopes.
- Subjects
CARBOHYDRATES; CELL membranes; AGGLUTINATION; ERYTHROCYTES
- Publication
FEBS Letters, 2006, Vol 580, Issue 6, p1691
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.02.006