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- Title
Neuronal traits are required for glucose-induced insulin secretion
- Authors
Abderrahmani, Amar; Niederhauser, Guy; Plaisance, Valérie; Haefliger, Jacques-Antoine; Regazzi, Romano; Waeber, Gérard
- Abstract
The transcriptional repressor RE1 silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreatic β-cells, we evaluated their role by generating a model of insulin-secreting cells that express REST. The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to secrete insulin in response to mitochondrial fuels, a particularity of mature β-cells, was impaired. These data provide evidence that REST target genes are required for an appropriate glucose-induced insulin secretion.
- Subjects
NEURONS; INSULIN; CELLS; GENES
- Publication
FEBS Letters, 2004, Vol 565, Issue 1-3, p133
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.04.002