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- Title
Does chloroquine really act through oxidative stress?
- Authors
Monti, Diego; Basilico, Nicoletta; Parapini, Silvia; Pasini, Erica; Olliaro, Piero; Taramelli, Donatella
- Abstract
To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO2 and 93% N2. Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.
- Subjects
CHLOROQUINE; PLASMODIUM; ERYTHROCYTES
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p3
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02881-8