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- Title
TNF-α genetic polymorphism −308G/A and antituberculosis drug-induced hepatitis.
- Authors
Kim, Sang-Heon; Kim, Sang-Hoon; Yoon, Ho Joo; Shin, Dong Ho; Park, Sung Soo; Kim, Youn-Seup; Park, Jae-Seuk; Jee, Young-Koo
- Abstract
Background While the mechanisms underlying the development of drug-induced liver injury are not clear, there is evidence to suggest that tumor necrosis factor-α (TNF-α) plays an important role in drug- or drug metabolite-induced immune responses. We hypothesized that polymorphisms in the TNF-α gene are associated with anti-tuberculosis drug (ATD)-induced hepatitis. Methods Patients who suffered from ATD-induced hepatitis were enrolled in the study. ATD-induced hepatitis was defined as an increase in liver transaminase levels that were more than three times the upper limit of normal. ATD-tolerant patients were used as a control. Patients were treated with first line ATD therapies including isoniazid, rifampicin, ethambutol, and pyrazinamide. We compared the genotype frequencies of the TNF-α polymorphism -308G/A in 77 patients with ATD-induced hepatitis and 229 ATD-tolerant patients. Results The frequency of carrying the variant allele (AG or AA) was significantly higher in patients with ATD-induced hepatitis compared with ATD-tolerant patients [26.0% vs. 15.3%, P = 0.034, OR (95% CI) = 1.94 (1.04-3.64)] and the frequency of the A allele was significantly different between the two groups [0.143 vs. 0.079, P = 0.018, OR (95% CI) = 1.95 (1.11-3.44)]. Conclusion These results reveal that the TNF-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This genetic variant may be a risk factor for ATD-induced hepatitis in individuals from Korea.
- Subjects
GENETIC polymorphisms; LIVER diseases; HEPATITIS; GENETIC research; ANTITUBERCULAR agents
- Publication
Liver International, 2012, Vol 32, Issue 5, p809
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2011.02697.x