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- Title
Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma.
- Authors
Ping-Ning Hsu; Tsuey-Ching Yang; Jung-Ta Kao; Ken-Sheng Cheng; Yi-Ju Lee; Yuan-Min Wang; Chin-Tung Hsieh; Cheng-Wen Lin; Yi-Ying Wu
- Abstract
Background/aims: Hepatitis B infection is a well-known cause of hepatocellular carcinoma (HCC). This study aims to investigate the role that the co-stimulatory molecule CD28 and co-inhibitory molecule programmed death-1 (PD-1) play in compromising the function of tumour-infiltrating lymphocytes (TIL) in hepatitis B virus (HBV)-related HCC. Methods: A total of 45 patients with HBV-related HCC were enrolled during the period February 2008 to March 2010. The immune phenotype and the expression of PD-1, CD28 and CD127 in TIL in biopsy specimens and in peripheral blood lymphocytes (PBL) from the same patients were analysed by flow cytometry. Results: Among the 45 patients, there was a male predominance (80%) and the mean age was 50 ± 13.68 years (range: 29–71). The majority of TIL were CD45RO+CD69+. PD-1 expression was higher and CD28 and CD127 expression levels were lower in TIL than in PBL. The prevalence of portal vein thrombosis was 40%. Furthermore, tumour thrombosis invasion into the portal vein correlated with the expression level of the PD-1 co-inhibitory molecule. Conclusion: PD-1+ tumour-infiltrating lymphocytes correlate with portal vein thrombosis and might serve as a potential prognostic marker of and a novel therapeutic target for HBV-related HCC.
- Subjects
HEPATITIS B virus; HEPATITIS B; CD antigens; LYMPHOCYTES; APOPTOSIS; PATIENTS
- Publication
Liver International, 2010, Vol 30, Issue 9, p1379
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2010.02323.x