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- Title
Capillary electrophoresis with electrochemiluminescence detection for the simultaneous determination of cisatracurium besylate and its degradation products in pharmaceutical preparations.
- Authors
Zuo, Ming; Gao, Jieying; Zhang, Xiaoqing; Cui, Yue; Fan, Zimian; Ding, Min
- Abstract
Capillary electrophoresis with electrochemiluminescence detection for the simultaneous analysis of cisatracurium besylate and its degradation products (laudanosine, quaternary monoacrylate) in pharmaceutical preparation was developed and fully validated. The significant parameters that influence capillary electrophoresis separation and electrochemiluminescence detection were optimized. The total analysis time of the analytes was 15 min. The linearities of the method were 0.1∼40.0 μg/mL for cisatracurium besylate and 0.04∼8.00 μg/mL for laudanosine, with correlation coefficients ( r) of 0.999 and 0.998, respectively. The detection limits (S/N = 3) were 83.0 ng/mL for cisatracurium besylate and 32.0 ng/mL for laudanosine. The intraday relative standard deviations of the analytes were <3.0%, and the interday relative standard deviations were <8.0%. The developed method was cost-effective, sensitive, fast, and resource-saving, which was suitable for the ingredient analysis in pharmaceutical preparation.
- Subjects
CAPILLARY electrophoresis; ELECTROCHEMILUMINESCENCE; STANDARD deviations; PHARMACEUTICAL chemistry; STATISTICAL correlation
- Publication
Journal of Separation Science, 2015, Vol 38, Issue 13, p2332
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201500092