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- Title
Droplet‐Based Microfluidics Reveals Insights into Cross‐Coupling Mechanisms over Single‐Atom Heterogeneous Catalysts.
- Authors
Moragues, Thomas; Giannakakis, Georgios; Ruiz‐Ferrando, Andrea; Borca, Camelia N.; Huthwelker, Thomas; Bugaev, Aram; de Mello, Andrew J.; Pérez‐Ramírez, Javier; Mitchell, Sharon
- Abstract
Single‐atom heterogeneous catalysts (SACs) hold promise as sustainable alternatives to metal complexes in organic transformations. However, their working structure and dynamics remain poorly understood, hindering advances in their design. Exploiting the unique features of droplet‐based microfluidics, we present the first in‐situ assessment of a palladium SAC based on exfoliated carbon nitride in Suzuki–Miyaura cross‐coupling using X‐ray absorption spectroscopy. Our results confirm a surface‐catalyzed mechanism, revealing the distinct electronic structure of active Pd centers compared to homogeneous systems, and providing insights into the stabilizing role of ligands and bases. This study establishes a valuable framework for advancing mechanistic understanding of organic syntheses catalyzed by SACs.
- Subjects
HETEROGENEOUS catalysts; MICROFLUIDICS; ORGANIC synthesis; X-ray spectroscopy; METAL complexes; PALLADIUM
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 20, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202401056