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- Title
Precise Epitope Organization with Self‐adjuvant Framework Nucleic Acid for Efficient COVID‐19 Peptide Vaccine Construction.
- Authors
Shen, Fengyun; Xiong, Zijian; Wu, Yumin; Peng, Rui; Wang, Yue; Sun, Lele; Fan, Chunhai; Liu, Zhuang
- Abstract
Peptide vaccines have advantages in easy fabrication and high safety, but their effectiveness is hampered by the poor immunogenicity of the epitopes themselves. Herein, we constructed a series of framework nucleic acids (FNAs) with regulated rigidity and size to precisely organize epitopes in order to reveal the influence of epitope spacing and carrier rigidity on the efficiency of peptide vaccines. We found that assembling epitopes on rigid tetrahedral FNAs (tFNAs) with the appropriate size could efficiently enhance their immunogenicity. Further, by integrating epitopes from SARS‐CoV‐2 on preferred tFNAs, we constructed a COVID‐19 peptide vaccine which could induce high titers of IgG against the receptor binding domain (RBD) of SARS‐CoV‐2 spike protein and increase the ratio of memory B and T cells in mice. Considering the good biocompatibility of tFNAs, our research provides a new idea for developing efficient peptide vaccines against viruses and possibly other diseases.
- Subjects
B cells; COVID-19 vaccines; T cells; PEPTIDES; IMMUNOLOGIC memory; IMMUNE response; VIRAL vaccines
- Publication
Angewandte Chemie, 2023, Vol 135, Issue 21, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202301147