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- Title
Addressing drug safety of maternal therapy during breastfeeding using physiologically‐based pharmacokinetic modeling.
- Authors
Pan, Xian; Rowland Yeo, Karen
- Abstract
In the absence of clinical lactation data, it may be possible to predict the passage of drugs into breast milk (M/P ratio) using only the physicochemical properties of the drug and milk characteristics. PREDICTING DRUG CONCENTRATIONS IN MILK The amount of drug excreted into breast milk depends upon the composition of the milk, the physicochemical properties of the drug, and the mechanism of transport. Once an estimate of drug concentration in milk is available, an infant daily dose assuming a daily milk intake of 150 ml/kg and a milk/plasma ratio can be calculated.
- Subjects
BREASTFEEDING; LACTATION; CYSTIC fibrosis transmembrane conductance regulator; MEDICATION safety; DRUG side effects; CHLORIDE channels
- Publication
CPT: Pharmacometrics & Systems Pharmacology, 2022, Vol 11, Issue 5, p535
- ISSN
2163-8306
- Publication type
Article
- DOI
10.1002/psp4.12802