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- Title
Telomeres and Cancer.
- Authors
Fan, Hueng-Chuen; Chang, Fung-Wei; Tsai, Jeng-Dau; Lin, Kao-Min; Chen, Chuan-Mu; Lin, Shinn-Zong; Liu, Ching-Ann; Harn, Horng-Jyh
- Abstract
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin complex, and the CST complex, synergizing with DNA replication, repair, and the RNA metabolism pathway components. As dysfunctional telomere maintenance and telomerase activation are associated with several human diseases, including cancer, the molecular mechanisms behind telomere length regulation and protection need particular emphasis. Cancer cells exhibit telomerase activation, enabling replicative immortality. Telomerase reverse transcriptase (TERT) activation is involved in cancer development through diverse activities other than mediating telomere elongation. This review describes the telomere functions, the role of functional modulators, the implications in cancer development, and the future therapeutic opportunities.
- Subjects
TELOMERES; TELOMERASE reverse transcriptase; TELOMERASE; RNA metabolism; DNA replication; CARCINOGENESIS
- Publication
Life (2075-1729), 2021, Vol 11, Issue 12, p1405
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life11121405