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- Title
Erythrocyte complement receptor type 1 (CR1) expression and circulating immune complex (CIC) levels in hydralazine-induced SLE.
- Authors
Mitchell, Jacqueline A.; Batchelor, J. R.; Chapel, Helen; Spiers, C. N.; Sim, Edith
- Abstract
Family studies were carried out to look at CR 1 expression in 24 hydralazine-induced SLE patients (Hz Reactors), who had been off the drug for at least 1 year and were clinically well at the time of the study. Mean expression of CRI was reduced by 27% in the group of hypertensives who had developed Hz-induced SLE compared with a group of .35 normal individuals. CRI expression was also slightly reduced in the relatives of the Hz Reactors compared to the normal group. Using a solid-phase Clq binding assay, CIC levels were found to be elevated in the plasma of the Hz reactors and an inverse relationship was found between CRI levels and CIC levels in this patient group. Both CRI levels and CIC levels in Hz Reactors and normal individuals were constant over the 36 weeks studied. This study suggests that there is an association between an inability to deal efficiently with CIC and susceptibility to developing Hz-induced SLE.
- Subjects
ERYTHROCYTES; GENE expression; HYDRALAZINE; PATIENTS; ANTIHYPERTENSIVE agents; IMMUNOASSAY
- Publication
Clinical & Experimental Immunology, 1987, Vol 68, Issue 2, p446
- ISSN
0009-9104
- Publication type
Article