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- Title
Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats.
- Authors
Thompson, H. S. G.; Staines, N. A.
- Abstract
Rats were per-gastrically dosed by gavage with collagen type II (CH) in solution and were shown, as a result, to be subsequently resistant to the induction of' disease by Cu administered parenterally in Freund's incomplete adjuvant. Disease onset was delayed and the severity was reduced. There was no concomitant reduction in the systemic antibody response to CH. Gavage with CH did not in itself induce systemic anti-Cu antibodies and did not cause symptoms of arthritis. The results indicate that materials specifically cross-reactive with autoantigens can he absorbed through the gut and can modify susceptibility to autoimmune disease.
- Subjects
COLLAGEN; IMMUNOLOGICAL adjuvants; ANTIGENS; CONNECTIVE tissues; LABORATORY rats; IMMUNOGLOBULINS
- Publication
Clinical & Experimental Immunology, 1986, Vol 64, Issue 3, p581
- ISSN
0009-9104
- Publication type
Article