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- Title
Hybrid esophagectomy for oesophageal cancer: long-term results. A single-centre experience.
- Authors
Hlaváčová, Lucie; Vrba, Radek; Neoral, Čestmír; Aujeský, René; Stašek, Martin; Chudáček, Josef; Vomáčková, Katherine; Vrána, David; Sněhota, Martin
- Abstract
Introduction: The authors report long-term outcomes in patients who received neoadjuvant chemoradiotherapy and consequently underwent hybrid oesophagectomy for oesophageal cancer (OC). Aim: To evaluate long-term outcomes in patients suffering from OC, who underwent hybrid oesophagectomy. Material and methods: Our cohort consisted of patients suffering from OC, who received neoadjuvant chemoradiotherapy. Hybrid esophagectomy was performed 8-10 weeks after oncological treatment. Results: Ninety-four patients underwent surgery for OC from 2011 to 2015. Histology revealed adenocarcinoma in 60.6%, squamous cell carcinoma (SCC) in 36.2%, and other type of cancer in 3.2%. Seventy-three (77.7%) patients with advanced stage (T3-4, N0-2, M0) were indicated to receive neoadjuvant chemoradiotherapy (nCRT). Trans-hiatal hybrid oesophagectomy was performed in 83 (88.3%) patients. Transthoracic hybrid oesophagectomy was performed in 11 (11.7%) patients. Histology of the resected specimens of 18 (24.7%) patients did not reveal OC, i.e. pathological complete response (pCR). In our cohort, we proved an association between occurrence of pCR and age as well as disease-free survival (DFS). The patients who presented with pCR were significantly younger - below 60 years of age (p = 0.017). They also showed significantly higher mean DFS (p = 0.004). Conclusions: Combined oesophagectomy with neoadjuvant chemoradiotherapy results in a better long-term outcome in patients suffering from oesophageal cancer. In our set of patients who underwent hybrid esophagectomy, satisfactory short-term and especially long-term results of surgical treatment for oesophageal cancer were observed.
- Subjects
ESOPHAGEAL cancer; CHEMORADIOTHERAPY; ESOPHAGECTOMY; SQUAMOUS cell carcinoma; PROGRESSION-free survival
- Publication
Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i Inne Techniki Mało Inwazyjne, 2021, Vol 16, Issue 2, p297
- ISSN
1895-4588
- Publication type
Article
- DOI
10.5114/wiitm.2020.100893