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- Title
Clinical characteristics of Korean patients with filaggrin-related atopic dermatitis.
- Authors
Park, K. Y.; Park, M. K.; Seok, J.; Li, K.; Seo, S. J.
- Abstract
Background Filaggrin is a key protein involved in skin barrier function. Mutations in the gene encoding filaggrin ( FLG) have been identified as the cause of ichthyosis vulgaris and have been shown to be major predisposing factors for atopic dermatitis ( AD). Aim To investigative the clinical characteristics of patients with AD with FLG mutations and determine the differences between patients with AD with and without FLG mutations. Methods We identified FLG mutations in patients with AD by complete sequencing and SNaPshot methods, and then analysed the data on clinical characteristics from questionnaire responses. Results We found that earlier age of AD onset ( P < 0.05), tendency to respiratory atopy ( P = 0.03), more severe clinical characteristics of AD (higher Eczema Area and Severity Index, P = 0.02) and decrease in skin hydration ( P = 0.04) were associated with FLG-related AD. Conclusion Our data demonstrate that FLG mutations are indicators of a poor prognosis in AD, and are predisposing factors that exist in early infancy and persist into adulthood.
- Subjects
FILAGGRIN; SKIN inflammation; ATOPIC dermatitis; ATOPY; INPATIENT care
- Publication
Clinical & Experimental Dermatology, 2016, Vol 41, Issue 6, p595
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.12854