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- Title
Different approaches to relating genotype to phenotype in developmental disorders.
- Authors
Karmiloff-Smith, Annette; Scerif, Gaia; Thomas, Michael
- Abstract
In this article, we discuss the complex problem of relating genotype to phenotype and challenge the simple mapping of genes to higher level cognitive modules. We examine various methods that have been used to investigate this relation including quantitative genetics, molecular genetics, animal models, and in-depth psychological and computational studies of developmental disorders. Both single gene and multiple gene disorders indicate that the relationship between genotype and phenotype is very indirect and that, rather than identifying mere snapshots of developmental outcomes, the process of ontogenetic development itself must be taken into account. © 2002 Wiley Periodicals, Inc. Dev Psychobiol 40: 311–322, 2002. DOI 10.1002/dev.10035
- Subjects
PHENOTYPES; DEVELOPMENTAL genetics; GENE mapping; MOLECULAR genetics; MATHEMATICAL models; ANIMAL models in research
- Publication
Developmental Psychobiology, 2002, Vol 40, Issue 3, p311
- ISSN
0012-1630
- Publication type
Article
- DOI
10.1002/dev.10035